Human studies have confirmed that vitamin B12 is also required for healthy telomeres. Vitamin D and telomere length have both been associated with various health outcomes, but there have been only a few studies on the relationship between them (Reference Richards, Valdes and Gardner 1 - Reference Julin, Shui and Prescott 4).Vitamin D is a hormone synthesised photochemically in the skin or ingested from foods and supplements that is subsequently hydroxylated in the liver to . Telomeres are the ends of chromosomes and undergo attrition with each replication ( 19, 20 ), a process that is accelerated by oxidative stress ( 21, 22 ). Key ingredients such as purslane, resveratrol, and vitamin D-3 are provided in doses used in scientific research. In other words, higher vitamin D = longer telomeres. "Human beings with the highest vitamin D levels have the longest telomeres, and people with the lowest vitamin D levels have the [shortest] telomeres," Gundry told mbg co-CEO Jason Wachob, referring to research in the Archives of Medical Science and the Journal of Nutrition on the association between telomere length and vitamin D levels. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. When participants who had the highest CRP and lowest vitamin D concentrations were compared with those who had the lowest CRP and highest vitamin D levels, the difference in telomere length was equivalent to 7.6 years of . Vitamin D supplementation has also been associated with protecting the length of telomeres. Influencing Telomere Length: The Long and Short of It ... Human studies have confirmed that vitamin B12 is also required for healthy telomeres. Higher levels of the vitamin D metabolite 25-hydroxyvitamin D may be correlated with longer telomeres in the genome. Shorter telomeres are associated with hyperglycemic levels and lower serum vitamin D levels. A study from 2007 has already shown that higher vitamin D concentrations are associated with longer leukocyte telomere length. The Effect of the Severity of Obstructive Sleep Apnea on ... Association of telomere length and serum vitamin D levels with type 2 diabetes mellitus and its related complications: A possible future perspective. Telomere length and associated factors in older adults ... ALL ABOUT TELOMERES - Chiro A study published in The Journal of Frailty & Aging found that higher vitamin D levels were associated with longer telomere length. Higher maternal vitamin D concentrations are associated ... Telomere length was also greater in those with lower C-reactive protein levels than in subjects with higher concentrations. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). They compared supplement intake with vitamin B6, B12, folate, calcium, and vitamin D versus just vitamin D and calcium. Vitamin D has many functions in the body, including its role in modulating inflammation—a mechanism that may protect telomeres as well. The association of telomere length and serum 25 ... 5 Ways To Keep Long And Healthy Telomeres | In Fitness And ... Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). T2DM has been considered as an age-related disease, it may be associated with TL. We investigated the association between maternal vitamin D concentrations and newborn leukocyte telomere lengths. So, preserving the length of your telomeres is the key to longevity. The present cross-sectional investigation evaluated the association between serum and dietary folate and vitamin B 12 levels and leukocyte telomere length, an index of cellular aging influenced by oxidative stress. Insufficient maternal vitamin D (25(OH)D) has also been associated with increased disease risk for many diseases and adverse later life outcomes. Richards JB, et al. However, direct relationships between 25-hydroxyvitamin D (25(OH)D) levels and TL are not well established. I Learned My Cellular Age. Here's How You Can, Too — Max ... Unless you are a sun baby, vitamin D is one nutrient that you might need to supplement with. Objective: The objective of the study was to examine whether vitamin D concentrations . The association of telomere length and serum 25 ... Higher maternal vitamin D concentrations are associated ... Dr. Yanbin Dong, geneticist and cardiologist at the Georgia Prevention Institute at the Medical . . 12) Iron users had a shorter telomere length than nonusers. Recent evidence suggests that longer Telomeres are linked to adequate levels of vitamin E with tocotrienols, vitamin C, vitamin D, omega-3 fatty acids and the antioxidant resveratrol. 54 -56 Telomere length is positively correlated with the levels of high-density lipoprotein, albumin, creatinine, and hemoglobin and the red blood cell count and negatively correlated with . Objective: Our aim was to assess the potential pro-tective role of active vitamin D treatment on telomere length in peripheral mononuclear cells (PBMC) from HD patients. Oats. Both vitamin D and telomere length are related with various health conditions, and vitamin D concentrations are associated with leukocyte telomere lengths in women. Then they measured homocysteine levels. In women, higher plasma 25-hydroxyvitamin D (25(OH)D) has been shown to be associated with longer telomere length, but the relationship has not been assessed in men. This study, published in November 2007 in the American Journal of Clinical Nutrition talks about the role of Vitamin D in aging. [box]Sponsored . Leukocyte telomere length (LTL) is a biomarker of biological aging, and has been associated with metabolic diseases such as type 2 diabetes (T2DM). Shen J, et al. Liu JJ, et al. Plasma vitamin D markers and leukocyte telomere length. In the present study, we examined the association between vitamin D and relative leukocyte telomere length by using both plasma 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) biomarkers. In a study by researchers from the London School of Medicine, serum vitamin D concentrations were measured in 2,160 women, aged 18 - 79 years (mean age: 49.4), from a large population-based cohort of twins. Adequate vitamin d levels show a positive association with telomere length. Similarly, human research has "Human beings with the highest vitamin D levels have the longest telomeres, and people with the lowest vitamin D levels have the [shortest] telomeres," Gundry told mbg co-CEO Jason Wachob, referring to research in the Archives of Medical Science and the Journal of Nutrition on the association between telomere length and vitamin D levels. Vitamins C and E preserve telomere length by reducing the chemical stresses that contribute to telomere shortening. They compared supplement intake with vitamin B6, B12, folate, calcium, and vitamin D versus just vitamin D and calcium. This was true whether vitamin D came from the sun, dietary sources or supplements. Introduction: Higher vitamin D levels and longer telomere length (TL) have been associated with lower risk of several chronic diseases and all-cause mortality.However, direct relationships between 25-hydroxyvitamin D (25(OH)D) levels and TL are not well established. A strong relationship also exists between vitamin D and telomere length. Telomeres. Telomeres are the ends of chromosomes and undergo attrition with each replication ( 19 , 20 ), a process that is accelerated by oxidative stress ( 21 , 22 ). Vitamin D could influence TL through its anti-inflammatory properties. Methods Average telomere length (ATL) in whole blood DNA samples was assessed with qPCR method in 53 Slovenian T1D children/adolescents (median age 8.7 years, 1:1.3 male/female ratio). DNA methylation (DNAm) age acceleration, a parameter derived via the epigenetic clock, has recently been suggested as a biomarker of aging. Vitamin D promotes activity of telomerase, the repair enzyme that steadily adds to telomere length. Vitamin D. Along with bone support, vitamin D plays a vital role in cellular processes, which grows the speculation that it may be beneficial in telomere biology. Telomeres are similar to those plastic tips on the end of shoelaces, that protect the threads of the shoelace from fraying. Telomere length was measured via PCR (polymerase chain reaction) on 4260 American adults ranging in age from 20 years old to over 60. ), published in the American Journal of Clinical Nutrition, analyzed data from 2,284 women who are part of the Nurses . And the women who took vitamin D supplements had longer telomeres that the women who didn't. 8. Telomere length, oxidative damage, antioxidants and breast cancer risk. Vitamin D and telomere length. * Presented as mean±SD. In the present study, we examined the association between vitamin D and relative leukocyte telomere length by using both plasma 25-hydroxyvitamin D (25 (OH)D) and 1,25-dihydroxyvitamin D (1,25 (OH)2D) biomarkers. A study conducted on 2,000 women and reported in the American Journal of Clinical Nutrition claims that the more vitamin D participants had, the longer their telomeres were. Sunlight also encourages your skin to make melanin, a natural sunscreen which gives your complexion its color. Other nutrients such as vitamin C, vitamin D, and omega-3 fatty acids levels were also associated with longer telomeres or attenuation of telomere shortening. Both vitamin D and omega-3 studies add to other evidence that diet and lifestyle factors that influence telomere length are those associated with inflammation and oxidative stress. Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. 29 Therefore, we aimed to explore . We hypothesized that accelerated biological aging, measured by both this new and the established biomarker of aging, relative leukocyte telomere length (rLTL), are associated with vitamin D deficiency. Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. Overview Identity Additional Document Info Overview. Like vitamin C, vitamin E can act as a potent antioxidant and influence telomere length. Significant Low levels of telomerase activity create short telomeres, which in turn signal exit from the cell cycle resulting in cell senescence and apoptosis. † p values for each group (intervention vs placebo) were derived from repeated-measures analysis of covariance adjusted for the respective baseline . Vitamin D - A scientific article published in 2017 in the "Journal of Nutrition" concluded that those individuals with low Vitamin D had shorter telomeres than those whose levels were adequate. And there's a relationship between how much melanin you have in your skin and the length of your telomeres. Length of telomeres should tell whether vitamin D, omega-3 are good for the heart, longevity. . [Wow] 11) Vitamin B-12 supplement users had a 5.9% longer telomere length than did nonusers. Vitamin D and telomere length. Maternal Vitamin D and Newborn Telomere Length Lisa Daneels, Dries S. Martens, Soumia Arredouani, Jaak Billen, Gudrun Koppen, Roland Devlieger, Tim S. Nawrot, Manosij Ghosh, Lode Godderis, Sara Pauwels; Affiliations Lisa Daneels Centre Environment & Health, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium . Background: Vitamin D is a potent inhibitor of the proinflammatory response and thereby diminishes turnover of leukocytes. AUGUSTA, Ga. (Nov. 14, 2016) - The length of your telomeres appears to be a window into your heart health and longevity, and scientists are measuring them to see if vitamin D and omega-3 . Bjelakovic G, Nikolova D, Gluud LL, et al. The inhibitory effect of vitamin D on the inflammatory response also points to a potential link between this vitamin and telomere dynamics (length and attrition rate) in leukocytes. Evidence suggests telomere length is a reliable indicator of overall health. Skip to main content Accessibility help We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Vitamin D and telomere length. Vitamin D is another vitamin touted as a panacea of health benefits, which include healthy telomeres. B vitamins preserve telomere length in part by lowering homocysteine, which accelerates telomere shortening. Sources: legumes, whole grains, nuts, seeds, and vegetable oils. The synergy of astragalus root, broccoli seed extract, rhodiola extract and Vitamin D 3, promotes telomerase activity to maintain telomere length to encourage cellular . Both micronutrients have been shown to reduce oxidative stress significantly. OGG1, 8-oxoguanine DNA glycosylase; TL, telomere length; 1,25(OH) 2 D 3, 1,25-dihydroxy-vitamin D; 25(OH)D 3, 25-hydroxy-vitamin D; 8-OXO-dG, 8-oxo-2 ′-deoxyguanosine. In one compelling twin study, sisters with higher levels of vitamin D had longer telomeres, correlating with 5 years of reduced cellular aging, even though both sisters were obviously the same chronological age. Leukocyte telomere length (LTL) is a predictor of aging-related disease and decreases with each cell cycle and increased inflammation. Double down on Vitamin D Vitamin D is a backbone nutrient of good health. It can be found in foods such as blue and fatty fish (salmon, tuna or sardine) mushrooms, dairy products and avocados however, the main source of . Both vitamin D and telomere length are related with various health conditions, and vitamin D concentrations were found to be positively associated with leukocyte telomere lengths in women . Then they measured homocysteine levels. Int J Cancer 2009;124:1637-1643. In the present study, we examined the association between vitamin D and relative leukocyte telomere length by using both plasma 25-hydroxyvitamin D (25 (OH)D) and 1,25-dihydroxyvitamin D (1,25 (OH) 2 D) biomarkers. Eur J Nutr 2016. Am J Clin Nutr 2007;86:1420-1425. Fasting for 12 hours each night at least 4 days per week is recommended. Leukocyte telomere length (LTL) will be measured using quantitative polymerase chain reaction method at the baseline, year 2 and year 4. we will examine the effect of randomization to vitamin D (primary Aim 1 and or fish oil (primary Aim 2) compared o placebo is different over time on changes in telomere length. In the age group of 40-59 years, blood levels of vitamin D were correlated to telomere length. Telomeres tend to get shorter as we age. Higher Serum Vitamin D Concentrations are Associated with Longer Leukocyte Telomere length in Women . Introduction: Higher vitamin D levels and longer telomere length (TL) have been associated with lower risk of several chronic diseases and all-cause mortality. In a study by researchers from the London School of Medicine, serum vitamin D concentrations were measured in 2,160 women, aged 18 - 79 years (mean age: 49.4), from a large population-based cohort of twins. [ 12-15 ] The blood levels of these nutrients are directly related to dietary intake from food or dietary supplements. ac-11® can benefit conditions like Parkinson's disease, rheumatoid arthritis, certain cancers, and viral illnesses . Evidence supporting this theory is mainly from studies in adults, whether vitamin D in children is a predictor of telomere length is unknown. For example, a study in 2010 (Cassidy et al. (Vitamin D is created in our bodies via our skins exposure to the UVB rays of the sun, but despite how easy this seems, the . Vitamin D supplementation has also been associated with protecting the length of telomeres. A total of 300 older adults aged 60 . Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. A new study adds to the already substantial evidence that vitamin D preserves telomere length and, so, could protect against aging. Nutrition is important during pregnancy for offspring health. This knowledge is what prompted researchers to explore the vitamin D/ telomere connection — and here's what they found… In 4,347 men and women aged between 42 and 49 years, evaluations of blood samples and telomeres were conducted. In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. * Presented as mean±SD. 29 Therefore, we aimed to explore . Plasma vitamin D markers and leukocyte telomere length. Vitamin D delays aging at genetic level. According to a 2017 research published in The Journal of Nutrition, people with low vitamin D (less than 50) had shorter telomeres than those with adequate vitamin D. ( over 50). A cross-sectional study suggests that higher serum 25 hydroxyvitamin D(25(OH)D) level is associated with longer leukocyte telomere length in 2160 Caucasian women. . The new study analyzed data from 1542 Americans between 20 and 39, 1336 people between 40 and 59 and 1382 people over 60. Drink water daily and use no caffeine. The association between maternal and cord blood total 25(OH)D and LTL was examined in mother-child . Source: The American Journal of Clinical Nutrition, November 2007 Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women Authors: Brent Richards, Ana . In a study by researchers from the London School of Medicine, serum vitamin D concentrations were measured in 2,160 women, aged 18 - 79 years (mean age: 49.4), from a large population-based cohort of twins. Turns out, it is also great for telomere regeneration and maintenance. Evidence show that shortened telomere length (TL) and low Vitamin D levels can increase the risk of type 2 diabetes mellitus (T2DM) and its associated complications. Fortunately, vitamin D can help preserve the length of telomeres. The study authors, however, conceded that while this suggested a link between vitamin D levels and telomere length, it did not provide unequivocal evidence that vitamin D was responsible for this effect, rather than some other factor unaccounted for in the research,. Shen J, et al. Active vitamin D treatment has been reported to have an effect on telomere length and beneficial effects on HD patients, but the mechanisms are unknown. Vitamin D biomarker levels and leukocyte telomere length were measured using plasma samples collected in 1989-1990 from participants of the Nurses' Health Study, a study of nurses from 11 US states. Therefore, this study aimed to identify neuroprotective factors for cognitive decline in different ageing groups. that higher serum vitamin D concentrations in 2160 women were positively significantly associated with leukocyte telomere length (P=0.001), and the difference in telomere length between those with the highest and lowest vitamin D intake was 107 base pairs, which is equivalent to 5 years of telomeric aging. [box]Sponsored . Vitamin D status has been associated with longer telomeres. Abstract Background: Obstructive sleep apnea (OSA) is a common disorder in which breathing repeatedly stops . Cochrane Database Syst Rev 2012, 3:CD007176. Ten nutrients support telomere length, cell health, and DNA health to support longer telomeres. One of the most important of these is ac-11® , an extract from a tropical woody vine called Uncaria tomentosa (or cat's claw ). Recent studies have shown that the availability of B and D vitamins and the concentrations of serum folate and homocysteine are correlated with the LTL. Vitamin D and telomere length. 1, 25-Dihydroxyvitamin D, the biological active form of vitamin D, possesses immunosuppressive properties [22]. Vitamin D status is a predictor of telomere length during pregnancy - Volume 71 Issue OCE2. A recent study published in the European Journal of Nutrition studied telomeres from 60 elderly people. Numerous studies have shown a direct link between adequate vitamin D levels and long, healthy telomeres. Another great source of vitamin D is nonfat dairy products. Vitamin D might influence telomere length due to anti-inflammatory activities, because inflammation could decrease telomere length. Vitamin D could influence TL through its anti-inflammatory properties. 1 Vitamin D is a potent inhibitor of the proinflammatory response and thereby diminishes the turnover of leukocytes. In a study by researchers from the London School of Medicine, serum vitamin D concentrations were measured in 2,160 women, aged 18 - 79 years (mean age: 49.4), from a large population-based cohort of twins. Higher serum vitamin D levels are associated with longer telomere length in women. Higher serum vitamin D levels are associated with longer telomere length in women. The Telomerin™ blend contained within Telomere Pro™ is the subject of a published study on the activation of Telomerase, the enzyme responsible for rebuilding telomeres. Am J Clin Nutr 2007;86:1420-1425. A cross-sectional study suggests that higher serum 25 hydroxyvitamin D(25(OH)D) level is associated with longer leukocyte telomere length in 2160 Caucasian women. Richards JB, et al. Purpose Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. Studies have shown that vitamin D, telomere length, and brain-derived neurotrophic factor (BDNF) have been associated with cognitive function. 3. Shorter telomeres are associated with increased health risk factors. Vitamin D supplementation has also been associated with protecting the length of telomeres. Every 10-nmol increase in levels of 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form of the vitamin) was associated with a .03-kbp longer telomere in leukocytes in middle-aged adults . Telomere length, oxidative damage, antioxidants and breast cancer risk. They are a great source of vitamin D, which is linked to telomere length. 10) Those that took antioxidant combination type multivitamins for > 5 years increased telomere length by 8%. Concentration of vitamin D in serum is associated positively with the telomere length in women [45]. † p values for each group (intervention vs placebo) were derived from repeated-measures analysis of covariance adjusted for the respective baseline . Liu JJ, et al. telomere length by 3%. One-carbon metabolites and telomere length in a prospective and randomized study of B- and/or D-vitamin supplementation. A recent study published in the European Journal of Nutrition studied telomeres from 60 elderly people. The Effect of the Severity of Obstructive Sleep Apnea on Leukocyte Telomere Length, 25 Hydroxy Vitamin D, and Parathyroid Hormonal Concentrations in Asian Indians Academic Article. Vitamin D supplementation has also been associated with protecting the length of telomeres. Int J Cancer 2009;124:1637-1643. Folate and vitamin B 12 are essential for a variety of metabolic processes. The more vitamin D in your body, the younger your DNA is, researchers at the London School of Medicine suggest in the American Journal of Clinical Nutrition. The detection and modification of prenatal factors affecting telomere length may help to ensure that an individual has the maximal telomere length at birth. A study published . The inhibitory effect of vitamin D on the inflammatory response also points to a potential link between this vitamin and telomere dynamics (length and attrition rate) in leukocytes. Evidence show that shortened telomere length (TL) and low Vitamin D levels can increase the risk of type 2 diabetes mellitus (T2DM) and its associated complications. OGG1, 8-oxoguanine DNA glycosylase; TL, telomere length; 1,25(OH) 2 D 3, 1,25-dihydroxy-vitamin D; 25(OH)D 3, 25-hydroxy-vitamin D; 8-OXO-dG, 8-oxo-2 ′-deoxyguanosine. 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